ACTIVATE YOUR ANTI-AGING GENES

by HEALTHCARE

Aging is a natural process of living organisms where there is a continuous decline in mechanical-biological functions.

Aging is an important risk factor for suffering from neurodegenerative, cardiovascular, metabolic diseases, malignant tumors (cancer) and other diseases associated with oxidative stress..

This process occurs as a consequence of the cumulative damage caused by various factors, including free radicals released in respiration and the environment, as well as the loss of cell proliferation capacity.

There are markers of aging such as mitochondrial dysfunction, cellular senescence (the irreversible arrest of cell proliferation in response to exogenous or endogenous stimuli), nutrient wasting and alteration of intercellular communication.

These processes are not necessarily independent of each other and often occur simultaneously in an interconnected manner (3).

The exact combination of nutrients in the Enikia © formula has a novel effect of stimulating the formation of new cells and, best of all, without proven evidence of genotoxicity.

The formulation of Enikia © evokes a cellular mechanism to promote tissue regeneration and the activation of genes involved in longevity such as sirtuin 1 and in antisenescence such as antioxidant enzymes and mitogen-activated kinase AMPK (4, 9, 11, 15, 23, 24).

Furthermore, in the early stage of aging, Enikia © provides protection and metabolic compensation so that cells resist the main triggers of aging, which are free radicals and cellular exhaustion.

Equilibrio y vitalidad

BALANCE AND VITALITY

Health is described in many ways, for example, it is considered as a dynamic condition of resilience to stressors and the...

Juntos en tu recuperación

TOGETHER IN YOUR RECOVERY

When people go through illness and do not eat properly, they tend to reduce their daily activities and use fat and muscle reserves for energy...

References

    1. Aoi W, Naito Y, Yoshikawa T. Exercise and functional foods. Nutr J. 2006 Jun 5;5:15. doi: 10.1186/1475-2891-5-15. PMID: 16749944; PMCID: PMC1526446.
    2. Astudillo de la Vega, H. (2016). Patent: Combination of metabolic bio-energetic and nutra-epigentic regulators, nutraceutical compounds in conventional and nanotechnologies combination to revert and prevent the chronic damage accelerated cellular senescence produced by diabetes and other (Patent No. Application US433 20160354331-A1). OA19128A – Combination of metabolic regulators and nutraceuticals for the prevention of chronic damage from diabetes. – Google Patents. https://patents.google.com/patent/OA19128A/en?q=(dela+vega)&inventor=astudillo&assignee=horacio&oq=horacio+astudillo+dela+vega. Accessed: 2023-08-08
    3. Baur, J. A. et al., (2006) . Resveratrol improves health and survival of mice on a high calorie diet. Nature, 444 (7117): 337-342.
    4. Beher, D., Wu, J., Cumine, S., Kim, K. W. , Lu, S. C., Atangan, L., Wang, M. (2009) . Resveratrol is not a direct activator of SIRT1 enzyme activity. Chem Biol Drug Des., 74 (6): 619-624. doi: 10.1111/j.1747-0285.2009.00901.x.PMID 19843076.
    5. Buford, B. N., & Koch, A. J. (2004). Glycine-arginine-α-ketoisocaproic acid improves performance of repeated cycling sprints. Medicine & Science in Sports & Exercise, 36(4), 583-587.
    6. , Kopp, B., Bauer, R., Stuppner, H., Dirsch, V. M. , Atanasov, A. G. (2014). Naturel product agonists of peroxisome proliferator-activated receptor gamma (PPARy): a review. Biochem Pharmacol 92 (1) : 73-89. doi: 10.1016/j.bcp.2014.07.018. PMC 4212005. PMID 25083916.
    7. Di Renzo, Laura, Paola Gualtieri, and Antonino De Lorenzo. «Diet, Nutrition and Chronic Degenerative Diseases» Nutrients13, no. 4: 1372. https://doi.org/10.3390/nu13041372
    8. Di Renzo, Laura, Paola Gualtieri, Lorenzo Romano, Giulia Marrone, Annalisa Noce, Alberto Pujia, Marco Alfonso Perrone, Vincenzo Aiello, Carmela Colica, and Antonino De Lorenzo. «Role of Personalized Nutrition in Chronic-Degenerative Diseases» Nutrients11, no. 8: 1707. https://doi.org/10.3390/nu11081707.
    9. Do, G. M. et al., (2008). Long-term effects of resveratrol supplémentation on suppression of atherogenic lésion formation and cholestérol synthesis in apo Edeficient mice. Biochem. Biophys. Res. Commun., 374(1): 55-59.
    10. Dodds W. Disease Now and Potential Future Pandemics. The World’s Worst Problems. 2019 Dec 3:31–44. doi: 10.1007/978-3-030-30410-2_4. PMCID: PMC7120200.
    11. Duffy, S. J., Vita, J. A. (2003). Effects of phenolics on vascular endothélial function. Current Opinion in Lipidology, 14 (1) : 21-27. doi:10.1097/01.mol.0000052857. 26236.f2, PMID 12544657.
    12. Jayanthi P, Joshua E, Ranganathan K. Ageing and its implications. J Oral Maxillofac Pathol. 2010 Jul;14(2):48-51. doi: 10.4103/0973-029X.72500. PMID: 21731262; PMCID: PMC3125059.
    13. Kerksick CM, Wilborn CD, Roberts MD, Smith-Ryan A, Kleiner SM, Jäger R, Collins R, Cooke M, Davis JN, Galvan E, Greenwood M, Lowery LM, Wildman R, Antonio J, Kreider RB. ISSN exercise & sports nutrition review update: research & recommendations. J Int Soc Sports Nutr. 2018 Aug 1;15(1):38. doi: 10.1186/s12970-018-0242-y. PMID: 30068354; PMCID: PMC6090881.
    14. Klöting, N.; Schwarzer, M.; Heyne, E.; Ceglarek, U.; Hoffmann, A.; Krohn, K.; Doenst, T.; Blüher, M. Intrinsic Exercise Capacity Affects Glycine and Angiotensin-Converting Enzyme 2 (ACE2) Levels in Sedentary and Exercise Trained Rats. Metabolites 2022, 12, 548. https://doi.org/10.3390/metabo12060548
    15. Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., Geny, B., Laakso, M., Puigserver, P., Auwerx, J. (2006). Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-lalpha. Cell 127 (6) : 1109-1122. doi:10.1016/j.cell.2006.11.013. PMID 17112576.
    16. Lodder, R. A., Cassis L. A. (2016). D-tagatose-based compositions and methods for preventing and treating atherosclerosis, metabolic syndrome, and symptoms thereof. Patent US 2015/9,060,962, Jun. 23, 2015.
    17. Marti-Centelles, R., Falomir, E., Murga, J., Carda, M., Marco, J. A. (2015). Inhibitory effect of cytotoxic stilbenes related to resveratrol on the expression of the VEGF, hTERT and c-Myc genes. Eur J Med Chem. 103: 488-496.
    18. Meuffels Frederike Maria, Isenmann Eduard, Strube Malte, Lesch Alessio, Oberste Max, Brinkmann Christian. xercise Interventions Combined With Dietary Supplements in Type 2 Diabetes Mellitus Patients—A Systematic Review of Relevant Health Outcomes. Frontiers in Nutrition;VOLUME 9;2022. https://www.frontiersin.org/articles/10.3389/fnut.2022.817724. doi:10.3389/fnut.2022.817724
    19. Mostafa Koohkan, Majid Vahidian-Rezazadeh, Reza Delavar, The Effect of Short-term Administration of High-dose Vitamins E and C on Serum Creatine Kinase and Myoglobin in the Resting Phase of Elite Sanda Athletes: A Randomized Trial, Asian Journal of Sports Medicine, 10.5812/asjsm-134047, 14, 2, (2023).
    20. Oleribe OO, Ukwedeh O, Burstow NJ, Gomaa AI, Sonderup MW, Cook N, Waked I, Spearman W, Taylor-Robinson SD. Health: redefined. Pan Afr Med J. 2018 Aug 24;30:292. doi: 10.11604/pamj.2018.30.292.15436. PMID: 30637076; PMCID: PMC6320447.
    21. Romero, T. (2016). Methods and materials for reducing multiple risk factors associated with the metabolic syndrome. Patent US 2016/9,278,104, Mar. 8, 2016. Vanhaecke, P., Persoone, G., Claus, C., Sorgeloos, P. (1981). Proposai for a short-term toxicity test with Artemia nauplii. Ecotoxicol Environ Saf. 5: 382-387.
    22. Rothschild JA, Kilding AE, Plews DJ. What Should I Eat before Exercise? Pre-Exercise Nutrition and the Response to Endurance Exercise: Current Prospective and Future Directions. Nutrients. 2020 Nov 12;12(11):3473. doi: 10.3390/nu12113473. PMID: 33198277; PMCID: PMC7696145.
    23. SIRT1 negatively régulâtes the mammalian target of rapamycin. PLoS ONE 5 (2): e9199. Bibcode:2010PLoSO. 5.9199G. doi: 10.1371/journal.pone.0009199.PMC 2821410.PMID 20169165.
    24. Sirtuins: novel targets for metabolic disease in drug development. Biochem. Biophys. Res. Commun. 373(3): 341-344.
    25. Varfolomeev, S. D. , Gurevich, K. G. (2001) . Enzyme active sites: bioinformatics, architecture, and mechanisms of action. Russian Chemical Bulletin. 50 (10): 1709-1717.
    26. Wu, G. A. B., Meininger, C. J., Knabe, D. A., Baze, F. W. A., Rhoads, J. M. (2000) Arginine nutrition in development, health and disease. Current Opinion in Clinical Nutrition & Metabolic Care. 3 (1) : 59-66.
    en_US