BALANCE AND VITALITY

by HEALTHCARE

Health is described in many ways, for example, it is considered as a dynamic condition of resilience to stressors and the possibility of recovering from everyday insults to maintain internal balance. On the other hand, it is also defined as a very positive concept that involves satisfactory states of physical, mental, economic, and social well-being.

On the other hand, diseases are abnormal states where the organism is compromised, either structurally or functionally (20).

All organisms known today have diseases, however, there are diseases that can cause premature death, for example, every year millions of people die from non-communicable diseases such as obesity, cardiovascular diseases, diabetes, kidney disease chronic, neurodegenerative diseases and many types of cancer.

Worldwide, patients with one or more non-communicable diseases represent more than 30% of the population, and 70 to 80% of public health resources are currently spent on the treatment of these diseases.

Premature mortality rates due to non-communicable diseases are very relevant and are considered a focus of attention for health authorities and the population in general, since, according to projections, by the year 2030, it is considered that the data will still become most worrying, representing 80% of all diseases in the world (7).

The main origins of these diseases are attributed especially to behavioral risk factors such as poor nutrition, high body mass index, smoking, drinking alcohol and performing little physical activity.

Therefore, the main measures to prevent projections from becoming real data are to modify behaviors such as diet.

In this regard, an adequate diet has symbolized the main object of protection or prevention of diseases and as a measure to achieve states of well-being and balance (10).

Within the approaches to support the treatment and prevention of diseases, several agents are being developed that are biologically composed of natural active ingredients such as nutraceuticals, which are consumed in the form of dietary supplements and/or as functional foods (8).

Molecular nutrition has opened a field of opportunities where in the prescription of a diet, each nutrient is not only part of the food to satisfy the appetite, but, through technical knowledge of its functioning at the cellular and organism level, can be considered the first actor in the prevention of diseases, becoming a drug in itself: “Let your food be your medicine and your medicine your food” (Hippocrates, father of modern medicine in the year 460 BC).

The enikia formulation was carefully selected by identifying mechanisms that trigger the most common non-communicable diseases such as obesity and diabetes.

The components of the enikia formula were evaluated in different study models, individually and as a complete formula, until the best effects were identified in systems that mimic disease states (as a way to improve disease symptoms) and in subjects healthy (as a form of prevention) (1, 12).

Enikia actively participates to promote well-being and balance by stimulating cellular cytoprotection against oxidation and chronic inflammation mechanisms, as well as the reactivation of several enzymatic cycles related to the metabolism of sugar, fatty acids and cholesterol, increasing the energy available in cells for greater functionality and vitality.

The examples of administration of the formula demonstrate that its intake is useful in healthy people, and in sick patients, it normalizes altered functions related to negative factors of diabetes, obesity and/or metabolic syndrome (1, 12).

Juntos en tu recuperación

TOGETHER IN YOUR RECOVERY

When people go through illness and do not eat properly, they tend to reduce their daily activities and use fat and muscle reserves for energy...

References

    1. Aoi W, Naito Y, Yoshikawa T. Exercise and functional foods. Nutr J. 2006 Jun 5;5:15. doi: 10.1186/1475-2891-5-15. PMID: 16749944; PMCID: PMC1526446.
    2. Astudillo de la Vega, H. (2016). Patent: Combination of metabolic bio-energetic and nutra-epigentic regulators, nutraceutical compounds in conventional and nanotechnologies combination to revert and prevent the chronic damage accelerated cellular senescence produced by diabetes and other (Patent No. Application US433 20160354331-A1). OA19128A – Combination of metabolic regulators and nutraceuticals for the prevention of chronic damage from diabetes. – Google Patents. https://patents.google.com/patent/OA19128A/en?q=(dela+vega)&inventor=astudillo&assignee=horacio&oq=horacio+astudillo+dela+vega. Accessed: 2023-08-08
    3. Baur, J. A. et al., (2006) . Resveratrol improves health and survival of mice on a high calorie diet. Nature, 444 (7117): 337-342.
    4. Beher, D., Wu, J., Cumine, S., Kim, K. W. , Lu, S. C., Atangan, L., Wang, M. (2009) . Resveratrol is not a direct activator of SIRT1 enzyme activity. Chem Biol Drug Des., 74 (6): 619-624. doi: 10.1111/j.1747-0285.2009.00901.x.PMID 19843076.
    5. Buford, B. N., & Koch, A. J. (2004). Glycine-arginine-α-ketoisocaproic acid improves performance of repeated cycling sprints. Medicine & Science in Sports & Exercise, 36(4), 583-587.
    6. , Kopp, B., Bauer, R., Stuppner, H., Dirsch, V. M. , Atanasov, A. G. (2014). Naturel product agonists of peroxisome proliferator-activated receptor gamma (PPARy): a review. Biochem Pharmacol 92 (1) : 73-89. doi: 10.1016/j.bcp.2014.07.018. PMC 4212005. PMID 25083916.
    7. Di Renzo, Laura, Paola Gualtieri, and Antonino De Lorenzo. «Diet, Nutrition and Chronic Degenerative Diseases» Nutrients13, no. 4: 1372. https://doi.org/10.3390/nu13041372
    8. Di Renzo, Laura, Paola Gualtieri, Lorenzo Romano, Giulia Marrone, Annalisa Noce, Alberto Pujia, Marco Alfonso Perrone, Vincenzo Aiello, Carmela Colica, and Antonino De Lorenzo. «Role of Personalized Nutrition in Chronic-Degenerative Diseases» Nutrients11, no. 8: 1707. https://doi.org/10.3390/nu11081707.
    9. Do, G. M. et al., (2008). Long-term effects of resveratrol supplémentation on suppression of atherogenic lésion formation and cholestérol synthesis in apo Edeficient mice. Biochem. Biophys. Res. Commun., 374(1): 55-59.
    10. Dodds W. Disease Now and Potential Future Pandemics. The World’s Worst Problems. 2019 Dec 3:31–44. doi: 10.1007/978-3-030-30410-2_4. PMCID: PMC7120200.
    11. Duffy, S. J., Vita, J. A. (2003). Effects of phenolics on vascular endothélial function. Current Opinion in Lipidology, 14 (1) : 21-27. doi:10.1097/01.mol.0000052857. 26236.f2, PMID 12544657.
    12. Jayanthi P, Joshua E, Ranganathan K. Ageing and its implications. J Oral Maxillofac Pathol. 2010 Jul;14(2):48-51. doi: 10.4103/0973-029X.72500. PMID: 21731262; PMCID: PMC3125059.
    13. Kerksick CM, Wilborn CD, Roberts MD, Smith-Ryan A, Kleiner SM, Jäger R, Collins R, Cooke M, Davis JN, Galvan E, Greenwood M, Lowery LM, Wildman R, Antonio J, Kreider RB. ISSN exercise & sports nutrition review update: research & recommendations. J Int Soc Sports Nutr. 2018 Aug 1;15(1):38. doi: 10.1186/s12970-018-0242-y. PMID: 30068354; PMCID: PMC6090881.
    14. Klöting, N.; Schwarzer, M.; Heyne, E.; Ceglarek, U.; Hoffmann, A.; Krohn, K.; Doenst, T.; Blüher, M. Intrinsic Exercise Capacity Affects Glycine and Angiotensin-Converting Enzyme 2 (ACE2) Levels in Sedentary and Exercise Trained Rats. Metabolites 2022, 12, 548. https://doi.org/10.3390/metabo12060548
    15. Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., Geny, B., Laakso, M., Puigserver, P., Auwerx, J. (2006). Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-lalpha. Cell 127 (6) : 1109-1122. doi:10.1016/j.cell.2006.11.013. PMID 17112576.
    16. Lodder, R. A., Cassis L. A. (2016). D-tagatose-based compositions and methods for preventing and treating atherosclerosis, metabolic syndrome, and symptoms thereof. Patent US 2015/9,060,962, Jun. 23, 2015.
    17. Marti-Centelles, R., Falomir, E., Murga, J., Carda, M., Marco, J. A. (2015). Inhibitory effect of cytotoxic stilbenes related to resveratrol on the expression of the VEGF, hTERT and c-Myc genes. Eur J Med Chem. 103: 488-496.
    18. Meuffels Frederike Maria, Isenmann Eduard, Strube Malte, Lesch Alessio, Oberste Max, Brinkmann Christian. xercise Interventions Combined With Dietary Supplements in Type 2 Diabetes Mellitus Patients—A Systematic Review of Relevant Health Outcomes. Frontiers in Nutrition;VOLUME 9;2022. https://www.frontiersin.org/articles/10.3389/fnut.2022.817724. doi:10.3389/fnut.2022.817724
    19. Mostafa Koohkan, Majid Vahidian-Rezazadeh, Reza Delavar, The Effect of Short-term Administration of High-dose Vitamins E and C on Serum Creatine Kinase and Myoglobin in the Resting Phase of Elite Sanda Athletes: A Randomized Trial, Asian Journal of Sports Medicine, 10.5812/asjsm-134047, 14, 2, (2023).
    20. Oleribe OO, Ukwedeh O, Burstow NJ, Gomaa AI, Sonderup MW, Cook N, Waked I, Spearman W, Taylor-Robinson SD. Health: redefined. Pan Afr Med J. 2018 Aug 24;30:292. doi: 10.11604/pamj.2018.30.292.15436. PMID: 30637076; PMCID: PMC6320447.
    21. Romero, T. (2016). Methods and materials for reducing multiple risk factors associated with the metabolic syndrome. Patent US 2016/9,278,104, Mar. 8, 2016. Vanhaecke, P., Persoone, G., Claus, C., Sorgeloos, P. (1981). Proposai for a short-term toxicity test with Artemia nauplii. Ecotoxicol Environ Saf. 5: 382-387.
    22. Rothschild JA, Kilding AE, Plews DJ. What Should I Eat before Exercise? Pre-Exercise Nutrition and the Response to Endurance Exercise: Current Prospective and Future Directions. Nutrients. 2020 Nov 12;12(11):3473. doi: 10.3390/nu12113473. PMID: 33198277; PMCID: PMC7696145.
    23. SIRT1 negatively régulâtes the mammalian target of rapamycin. PLoS ONE 5 (2): e9199. Bibcode:2010PLoSO. 5.9199G. doi: 10.1371/journal.pone.0009199.PMC 2821410.PMID 20169165.
    24. Sirtuins: novel targets for metabolic disease in drug development. Biochem. Biophys. Res. Commun. 373(3): 341-344.
    25. Varfolomeev, S. D. , Gurevich, K. G. (2001) . Enzyme active sites: bioinformatics, architecture, and mechanisms of action. Russian Chemical Bulletin. 50 (10): 1709-1717.
    26. Wu, G. A. B., Meininger, C. J., Knabe, D. A., Baze, F. W. A., Rhoads, J. M. (2000) Arginine nutrition in development, health and disease. Current Opinion in Clinical Nutrition & Metabolic Care. 3 (1) : 59-66.
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